Advances in Vascular Medicine by Ioannis Papaioannou, James S. Owen (auth.), David Abraham,

By Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

Understanding the numerous advanced mobile and molecular mechanisms underlying human vascular illnesses is vital in enhancing the administration of sufferers with this clinically very important and wide-ranging workforce of ailments. this is often relatively very important while contemplating the level of this factor around the world.

Written by means of a staff of world-renowned professionals, Advances in Vascular Medicine highlights many of the relationships among uncomplicated technological know-how and scientific medication, and reports either study and scientific perform tools and results in vascular biology and pathobiology. it truly is an authoritative reference for those vital issues of vascular biology and comprises chapters that specify the medical matters to the elemental scientist in addition to offering clinicians with a systematic grounding in vascular illnesses. even though there's nonetheless a lot paintings to be performed to strengthen figuring out of vascular sickness, the data and insights contained during this booklet are a necessary contribution to the literature, giving scientists and clinicians the chance to benefit extra approximately this fascinating box of biomedicine.

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2007;8:3. 41. Dekker M, Brouwers C, te Riele H. Targeted gene modification in mismatch-repair-deficient embryonic stem cells by single-stranded DNA oligonucleotides. Nucleic Acids Res. 2003;31:e27. 42. Yoon K, Cole-Strauss A, Kmiec EB. Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA-DNA oligonucleotide. Proc Natl Acad Sci U S A. 1996;93:2071–2076. 43. Cole-Strauss A, Yoon K, Xiang Y, et al. Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide.

4 Nongenetic Targeting A simple way of altering vector tropism without genetic modification is the coating of the viral particle with a bispecific antibody. One domain of the bispecific molecule binds to the virus capsid, while the other domain binds to a novel receptor thus acting as a molecular bridge.

Isolated targeting peptides can be genetically incorporated into the HI loop of the fiber of Ad19p between amino acids 331 and 332. Kidney targeting peptides HTTHREP and HITSLLS, which were identified through in vivo phage display, were incorporated into Ad19p-pseudotyped vectors. 4 Nongenetic Targeting A simple way of altering vector tropism without genetic modification is the coating of the viral particle with a bispecific antibody. One domain of the bispecific molecule binds to the virus capsid, while the other domain binds to a novel receptor thus acting as a molecular bridge.

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