Advances in Pharmacology and Chemotherapy Volume 19 by Silvio Garattini

By Silvio Garattini

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Chem. 10, 668-672. Montgomery, J. , Mayo, J . G . , and Hansch, C. (1974). J . Med. Chem. 17, 477-480. Montgomery, J . A . , McCaleb, G . S . , Kirk, M. , and Johnston, T. P. J . Med. C/iem. 18, 586-590. Montgomery, J . A . , McCaleb, G . S . , Johnston, T. , Mayo, I . G . , and Laster, W. R. (1977a). J . ,Wed. C / i ~ m20, . 291-295. Montgomery, J. A . Johnston, T. , Thomas, H . J . , Piper, J . , and Temple, C. (1977b). Atti.. C l i r o m t r ~ o , ~15, r . 169- 195. Mori, K. J . , MacDonald, J .

H . , Zito. D. , and Walker, M. D. (1977). \. 37, 2262-2266. , and Sargent, S. (1978). Riochetn. Phrrrmtrcol. 27. 1359-1363. Hung, D. , Deen, D. , and Marton, L. J. (1981). Ctrnrcv R t l . 41, 27832785. Johnston, T. , and Opliger, P. S. J . M d . Clrrni. 10, 675-681. Johnston, T. , McCaleb, G . , and Montgomery, J . A. (1963). J . M e d . Clrrrn. 6, 669-681, Johnston, T. , McCaleb, G . , Opliger, P. , and Montgomery, J. A. (1966). J . Mrci. Cheor. 9 , 892-91 I . Johnston, T. , McCaleb, G . , Opliger, P.

Cell toxicity could then result from DNA cross-linking (Kohn, 1977; Tong and Ludlum, 1981) or 1977) in a nucleic acid strand breaks (Erikson et l i / . , variety of cell types. As yet undiscovered membrane interactions or inactivation of sensitive enzymes could lead to cell death but these are less likely to be common features of several cell types or to be independent of the parent molecular structure. , 1978; Ewig and Kohn, 1978; Lown and McLaughlin, 1979b; Tong and Ludlum, 1979, 1980),(4) regulation of ribosomal RNA synthesis and processing to inhibit protein synthesis and thus inhibit cell growth (Walker and Gehan, 1972; Penman e f d .

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