Advances in Immunology, Vol. 31 by Henry G. Kunkel (ed.), Frank J. Dixon (ed.)

By Henry G. Kunkel (ed.), Frank J. Dixon (ed.)

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Using radioactive proteins, we were able to estimate that the amounts of both proteins bound to the macrophage were similar to the amount of DNP-hemocyanin bound to macrophages. The results indicated that lymphocytes would respond weakly to the unlinked hapten and carrier determinants on the same macrophage, but strongly if the determinants are bound in the same molecule (Fig. 3). 2. , to ask how essential the accessory cells are for the B-T cell interactions to take place. An early approach was to deplete accessory cells, usually from spleen, on the basis of their adhesion to culture dishes.

They also found a marked improvement of cell viability by addition of the thiol; while nonadherent cells showed a poor recovery, about 3% of initial input recovered after 4 days, the addition to them of macrophages or 2-ME resulted in about 30%recovery. A logical conclusion was that at least one effect of 2-ME must be through its improvement of cell survival. , 1974),the issue is that 2-ME clearly had other major effects that resulted in an increase in cell growth. The results of Click et al. are not contradictory to those of Chen and Hirsch inasmuch as the former used unfractionated spleen cells; in Click's experiments, it was possible to observe a marked enhancement of a response by 2-ME without a marked effect on cell viability.

Carrier-specific helper T cells were generated, inducing a small to modest number of plaque-forming cells with rather large experimental variations. Nevertheless, the results in the various publications appeared to be highly consistent. The generation of helper T cells to hemocyanin or to (TG)-AL required the presence of accessory phagocytic cells in the culture. The 2-ME did not replace the need for macrophages. Macrophages pulsed with the antigen were also highly efficient in generating helper T cells.

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